Research – PEMF treatment for Arthritis
Low frequency pulsed electromagnetic field–a viable alternative therapy for arthritis.
“The analysis of various studies (animal models of arthritis, cell culture systems and clinical trials) reporting the use of PEMF for arthritis cure has conclusively shown that PEMF not only alleviates the pain in the arthritis condition but it also affords chondroprotection, exerts anti-inflammatory action and helps in bone remodeling and this could be developed as a viable alternative for arthritis therapy.”
Department of Biotechnology, Central Leather Research Institute, Adyar, Chennai 600 020, India.
Ganesan K1, Gengadharan AC, Balachandran C, Manohar BM, Puvanakrishnan R.
Optimization of pulsed electromagnetic field therapy for management of arthritis in rats.
“Histological studies confirmed reduction in inflammatory cells infiltration, hyperplasia, and hypertrophy of cells lining synovial membrane. PEMF was also shown to have a membrane stabilizing action by significantly inhibiting the rate of release of beta-glucuronidase from lysosomal rich and sub-cellular fractions. The results indicated that PEMF could be developed as a potential therapy in the treatment of arthritis in humans.”
Department of Pharmacology and Toxicology, Madras Veterinary College, Vepery, Chennai, India.
Kumar VS1, Kumar DA, Kalaivani K, Gangadharan AC, Raju KV, Thejomoorthy P, Manohar BM, Puvanakrishnan R.
Pulsed electromagnetic fields stimulation affects BMD and local factor production of rats with disuse osteoporosis
“The results found demonstrate that PEMF stimulation can efficiently suppress bone mass loss. We, therefore, conclude that PEMF may affect bone remodeling process through promoting TGF-beta1 secretion and inhibiting IL-6 expression.”
Department of Orthopaedics, Third Affiliated Daping Hospital, Research Institute of Surgery, Third Military Medical University, Chongqing, PR China
Pulsed electromagnetic fields reduce acute inflammation in the injured rat-tail intervertebral disc.
“These data demonstrate that previously reported anti-inflammatory effects of PEMF on disc cells carry over to the in vivo situation, suggesting potential therapeutic benefits.”
Department of Neurological Surgery University of California San Francisco San Francisco California.
Department of Orthopaedic Surgery University of California San Francisco California.
Orthofix Inc. Lewisville Texas.
Chan AK, Tang X, Mummaneni NV, Coughlin D, Liebenberg E, Ouyang A, Dudli S, Lauricella M, Zhang N, Waldorff EI, Ryaby JT, Lotz JC.
Pulsed electromagnetic field (PEMF) treatment reduces expression of genes associated with disc degeneration in human intervertebral disc cells.
“These results demonstrate that IVD cells are responsive to PEMF and motivate future studies to determine whether PEMF may be helpful for patients with IVD degeneration.”
Department of Orthopaedic Surgery, University of California, 513 Parnassus Ave, S-1161, Box 0514, San Francisco, CA, 94143, USA.
Orthofix, Inc., 3451 Plano Parkway, Lewisville, TX 75056, USA.
Department of Orthopaedic Surgery, University of California, 513 Parnassus Ave, S-1161, Box 0514, San Francisco, CA, 94143, USA.
Miller SL, Coughlin DG, Waldorff EI, Ryaby JT2, Lotz JC.
Pulsed Electromagnetic Fields Reduce Interleukin-6 Expression in Intervertebral Disc Cells Via Nuclear Factor-κβ and Mitogen-Activated Protein Kinase p38 Pathways.
“Our data indicate that the previously-reported inhibitory effect of PEMF treatment on disc inflammation is mediated by NF-κβ and phosphorylated p38-MAPK signaling pathways. These results further establish PEMFs anti-inflammatory activity, and may inform potential future clinical uses for management of inflammation associated with disc degeneration.”
Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA.
Orthofix Inc., Lewisville, TX.
Tang X, Coughlin D, Ballatori A, Berg-Johansen B, Waldorff EI, Zhang N, Ryaby JT, Aliston T, Lotz JC.
Circadian rhythm affects the preventive role of pulsed electromagnetic fields on ovariectomy-induced osteoporosis in rats.
“Pulsed electromagnetic fields (PEMF) have been proved effective in the prevention of osteoporosis both experimentally and clinically. Chronotherapy studies have shown that circadian rhythm (CR) played an important role in the occurrence, development, and treatment of several diseases. CR has also been recognized as an essential feature of bone metabolism. Therefore, it is of therapeutic significance to investigate the impact of CR on the efficacy of PEMF in the prevention of osteoporosis.”
“The results indicated that CR was an important factor determining the preventive effect of PEMF on osteoporosis and PEMF exposure in the daytime presented better stimulus efficacy in rats. The findings might be helpful for the efficacious use of PEMF mediations, evaluation of PEMF action and experimental design in the future studies of biological effect of electromagnetic fields.”
Faculty of Biomedical Engineering, Fourth Military Medical University, 17 West Changle Road, Xi’an 710032, China.
Jing D, Shen G, Huang J, Xie K, Cai J, Xu Q, Wu X, Luo E.